Researchers are searching for clinical trials to the effectiveness of marijuana for treating opioid use disorder after a recently published study found that cannabis can alleviate many common signs of opioid withdrawal.
Of the 125 respondents who used marijuana to deal with their withdrawal, almost three-quarters (72% ) said it eased their symptoms, although only 6.4 percent said that it made them worse. Still another 20 percent reported mixed effects, and three individuals (2.4% ) stated cannabis did not appear to have a clear effect in any event.
“These results reveal that cannabis can improve opioid withdrawal symptoms and the size of the result is clinically significant.”
From the introduction to their paper, the investigators recognize that”these approvals are about due to the limited and contradictory evidence indicating cannabis can both enhance and aggravate opioid withdrawal and treatment retention”
The outcomes of the new study, however, suggest that cannabis is doing much more to ease opioid withdrawal symptoms compared to create them worse. Of 18 frequent symptoms that the researchers analyzed, participants on average stated that cannabis helped facilitate each one.
“Around all symptoms, more participants suggested that symptoms improved with cannabis in contrast to people who signaled symptoms associated with cannabis,” the study found. “Ratios representing the participants that experienced enhanced versus worsened symptoms suggested that more people found cannabis to improve instead of worsen all assessed symptoms”
“Stress is the most common opioid withdrawal symptom enhanced using cannabis.”
“Generally, withdrawal severity scores almost climbed on days cannabis wasn’t properly used,” the study found. The outcomes also whined that individuals with”higher cannabis and opioid usage experience larger reductions in opioid withdrawal if using cannabis.”
Participants were recruited with the Amazon Mechanical Turk (AMT) system, a task-based crowdsourcing marketplace.
“One limitation of the study,” the investigators confessed,”is that it had been conducted employing a brand new platform and, thus, in-person approval of material use wasn’t possible.” But they noted that”studies have supported using AMT for chemical use–related study by assessing MTurk data with information gathered in on site laboratory configurations.”
“The SOWS hasn’t been specifically assessed for use as a retrospective step,” the Johns Hopkins investigators wrote. “But given the paucity of the information on this subject, the strategy provided a viable means to identify whether particular withdrawal symptoms could be differentially influenced by cannabis use and the perceived size of the impact of cannabis use on symptom severity” Together, those factors”can be employed to encourage prospective evaluation of the subject.”
The investigators do not really conclude that cannabis is advantageous for individuals experiencing opioid withdrawal, but they also admit that their information points to the need for further, more rigorous research.
“These data imply that the co-users of both opioids and cannabis endorse cannabis as a way of reducing opioid withdrawal treatment,” the analysis states. “Given that the changing legal landscape, prospectively designed clinical trials that evaluate if cannabis or its elements can efficiently treat opioid withdrawal are justified.”
Although the issue is far from settled science, lots of different research in the last few years have indicated that cannabis might help lessen opioid use or dependence. One of these, a study published in December found that countries with authorized marijuana saw declines in opioid prescriptions. Another research from November of last year concluded that regular cannabis use decreased opioid consumption among chronic pain sufferers .
The national government is urging researchers to further investigate the function of cannabinoids in supplying safer painkilling options to opioids by making funds available for these research.